BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region

  • Khuon, D. [1], Rupasinghe, D. [2], Saphonn, V. [3], Kwong, T. S. [4], Widhani, A. [5], Chaiwarith, R. [6], Ly, P. S. [7], Do, C. D. [8], Avihingsanon, A. [9], Khusuwan, S. [10], Merati, T. P. [11], Van Nguyen, K. [12], Kumarasamy, N. [13], Chan, Y. J. [14], Azwa, I. [15], Ng, O. T. [16], Kiertiburanakul, S. [17], Tanuma, J. [18], Pujari, S. [19], Ditangco, R. [20], Zhang, F. [21], Choi, J. Y. [22], Gani, Y. [23], Sangle, S. [24], Ross, J. [25], Gorbach, P. M. [26], Jiamsakul, A. [27],
  • HIV Medicine
  • Access here
  • June 24, 2022
BIBLIOGRAPHY

Khuon, D., Rupasinghe, D., Saphonn, V., Kwong, T. S., Widhani, A., Chaiwarith, R., Ly, P. S., Do, C. D., Avihingsanon, A., Khusuwan, S., Merati, T. P., Van Nguyen, K., Kumarasamy, N., Chan, Y. J., Azwa, I., Ng, O. T., Kiertiburanakul, S., Tanuma, J., Pujari, S., Ditangco, R., Zhang, F., Choi, J. Y., Gani, Y., Sangle, S., Ross, J., Gorbach, P. M., & Jiamsakul, A. (2022). BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region. HIV medicine. https://doi.org/10.1111/hiv.13351
ABSTRAK

Background: Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations.

Methods: This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (<18.5 kg/m2 ), normal (18.5-22.9 kg/m2 ), overweight (23-24.9 kg/m2 ), and obese (≥25 kg/m2 ). High FBG was defined as a single post-ART FBG measurement ≥126 mg/dL. Factors associated with high FBG were analyzed using Cox regression models stratified by site.

Results: A total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29-41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2 ) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31-2.44; p < 0.001) and older age compared with those aged ≤30 years (31-40 years: HR = 1.47; 95% CI 1.08-2.01; 41-50 years: HR = 2.03; 95% CI 1.42-2.90; ≥51 years: HR = 3.19; 95% CI 2.17-4.69; p < 0.001).

Conclusion: People living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.
ABSTRAK YANG BERHUBUNGAN