Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia

  • Kurniawan, A. [1], Dwintasari, S. W. [2], Connelly, L. [3], Nichols, R. A. [4], Yunihastuti, E. [5], Karyadi, T. [6], Djauzi, S. [7],
  • Annals of epidemiology
  • 23
  • Access here
  • Nov. 1, 2013
BIBLIOGRAPHY

Kurniawan, A., Dwintasari, S. W., Connelly, L., Nichols, R. A., Yunihastuti, E., Karyadi, T., & Djauzi, S. (2013). Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia. Annals of epidemiology, 23(11), 720–723. https://doi.org/10.1016/j.annepidem.2013.07.019
ABSTRAK

Purpose: Cryptosporidium is an opportunistic parasite that manifests as chronic and severe diarrhea in the immune-compromised subject. We investigated the species of Cryptosporidium to understand the epidemiology, mode of transmission, response to treatment, and prevention.

Methods: Polymerase chain reaction/restriction fragment length polymorphism of the 18 S rRNA gene and sequencing were performed on 41 Cryptosporidium-positive stools from 36 patients with HIV AIDS, which comprised 36 pretreatment stools and 5 stools after treatment with Paromomycin.

Results: C. hominis, C. meleagridis, C. felis, and C. parvum were detected; 28 of 36 (77.7%) patients were infected with C. hominis and two (5.5%) patients with multiple species of Cryptosporidium. Treatment with Paromomycin resulted in different outcomes, perhaps because patients harbored other intestinal parasitic infections.

Conclusions: Multiple infection with various Cryptosporidium species in the presence of other intestinal parasites occurs in patients with HIV AIDS suffering from chronic diarrhea who are severely immune-compromised. Common transmission of Cryptosporidium is anthroponotic.
ABSTRAK YANG BERHUBUNGAN