HCV co-infection among people living with HIV Is associated with Higher fracture risk

  • Pramukti, I. [1], Liu, H. Y. [2], Chen, C. C. [3], Chen, Y. C. [4], Yeh, C. Y. [5], Fetzer, S. [6], Ibrahim, K. [7], Tai, T. W. [8], Ko, W. C. [9], Ko, N. Y. [10],
  • Journal of Infection & Public Health
  • 13
  • Access here
  • Nov. 1, 2020
BIBLIOGRAPHY

Pramukti, I., Liu, H. Y., Chen, C. C., Chen, Y. C., Yeh, C. Y., Fetzer, S., Ibrahim, K., Tai, T. W., Ko, W. C., & Ko, N. Y. (2020). HCV co-infection among people living with HIV Is associated with Higher fracture risk. Journal of Infection and Public Health, 13(11), 1724–1728. https://doi.org/10.1016/j.jiph.2020.06.020
ABSTRAK

Introduction: The purpose of this study was to predict the 10-year risk of fracture among people living with HIV (PLWH) using FRAX™, and to determine the risk factors related to a high probability of fractures.

Methodology: This study consisted of 288 subjects aged 40 years and above. The ten-year probability of major osteoporotic fractures (MOF) and hip fractures was assessed using the FRAX™ algorithm with bone mineral density (BMD) data. A logistic regression was used to determine risk factors related to a high probability of major osteoporotic fracture and hip fracture.

Results: The median 10-year probability of fracture was 3.7% (IQR 2.2-6.2) for MOF and 0.8% (IQR 0.3-2.5) for hip fractures. In addition to old age, previous fracture history, and low T-scores, HCV co-infection was associated with a higher risk of hip fractures in PLWH (AOR: 4.3, 95% CI: 1.29-14.33). Old age and low T-scores were also associated with a high probability of MOF.

Conclusions: HCV co-infection among PLWH is associated with a higher risk of hip fracture. Sustained efforts in terms of pharmacologic and non-pharmacologic interventions in PLWH are necessary to prevent osteoporotic fractures, especially in those with HCV co-infections.
ABSTRAK YANG BERHUBUNGAN